MIARE: Minimum Information About an RNAi Experiment : RNAi

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Key feature of RNA Interference (RNAi)
  1. Presence of double stranded RNA (dsRNA) in cell.
  2. Binding of siRNA to complementary mRNA in the RNA-induced silencing complex (RISC).
  3. Degradation of the mRNA by argonaute, the catalytic component of the RISC.

Definitions









  • The process by which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and occurs through a specific decrease in the level of mRNA of both host genes and transgenes. Gene Ontology



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